Delivering Bioactives

Delivering Bioactives

Research Lead: Dr Alf Garcia-Bennett, Macquarie University

The bioavailability of antioxidants, vitamins and other macronutrients is well known to be affected by the complex matrix (carbohydrate, polysaccharide, lipid etc.) around the active. Release of the nutrient from the food matrix, digestive enzymes, binding and uptake by the intestinal mucosa, transfer across the gut wall to the blood or lymphatic circulation, systemic distribution, metabolic and functional use, and excretion, all affect nutrient bioavailability. This Theme will focus on a range of bioactives to provide an analytical and experimental framework for delivery of a range of poorly soluble bioactive molecules, evaluating key differences in bioavailability between diverse matrices and formulations as well as the potential for varying administration routes.

Of importance are the unique analytical capabilities available within FAAB for the characterisation of bioactives within complex formulations (DSC/TGA, XRD, N2-Sorption isotherms, TEM, SEM, etc.) in combination with in vitro dissolution validation of formulations (USP-I,II dissolution equipment, automated UV-sampling, HPLC, etc.) as well as the in vivo pharmacokinetic assessment to understand the physical properties of the formulations available at MQ Animal Research Services. Statistical sampling, accelerated aging, sophisticated instrumental methods (electron, optical and probe microscopies; ICP-MS, NMR; Raman, IR and UV-spectroscopy, HPLC, in situ dissolution studies and pharmacokinetic studies) will be key to complete identification and characterisation of different formulations for oral and dermal delivery.

Identifying Functional Bioactives

FAAB delivers the advanced chemical and biological analysis and expertise required to discover, isolate, identify, and structurally characterise diverse bioactive compounds, in pace with expectations of the pharmaceutical and biotechnology sectors.

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Enhancing Bioactives

FAAB increases understanding of bioactives in their complex product matrix, at a molecular and microbiome level, to enhance potential therapeutic effectiveness, and together with commercial partners, derive new potential from food waste streams and controlled processing.

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